Title : Functionalizing chitosan-eugenol nanoparticles against Aeromonas hydrophila in channel catfish, an antibiotic alternative
Abstract:
Aquaculture is a growing global industry. Aeromonas hydrophila causes significant economic loss to fish farmers. The only FDA approved drug to treat this bacterial disease is Oxytetracycline. The excessive use of this drug has caused bacterial resistance and antibiotic residual problems in fish tissues. As a result, there is an urgent need to find alternative therapeutics and prophylactics to treat this fish bacterial disease. Plant spice materials have antimicrobial compounds that have therapeutic potential to treat diseases. Syzygium aromaticum, Clove plant, is safe to use and has no significant side effects when tested for the ability to induce cytotoxicity, genotoxicity or effect cell growth in CCO cells. Crustacean shells also have antimicrobial benefits that has the potential to treat diseases. The bactericidal effects of Syzygium aromaticum, Clove, and Chitin from Crustacean shells against Aeromonas hydrophila was significantly higher or equivalent to oxytetracycline. Chitin from crustacean shells and eugenol oil extract from the clove plant have a synergistic relationship where they complement each other and work very well together. In this research we used Chitin and eugenol encapsulation to make nanoparticles. Nanoparticles are materials with a size ranging from 1 to 100 nanometers. They easily cross cell and tissue barriers. This allows them to be used in drug delivery. This abstract is for the Graduate-Oral presentation.
